Regulation of cell fate specification

Across TCGA cell cohorts, RNA activity of the Regulation of cell fate specification pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP1, FAM117B, and RBBP4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell fate specification activity versus PARP1 in PANCREAS (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PARP1 →	+1.174	+1.336	.004	.009	3	10
BLOOD_Leukemia	FAM117B →	+1.031	+0.329	<.001	<.001	3	9
LARGE_INTESTINE	RBBP4 →	+0.977	+1.002	<.001	.002	3	8
PANCREAS	TFAP4 →	+1.021	+1.476	.002	.001	3	8
SOFT_TISSUE	ILF3 →	+1.286	+1.703	<.001	.001	3	8
LARGE_INTESTINE	NASP →	+0.562	+0.909	<.001	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042659 vs PARP1 — PANCREAS

Explore this scatter interactively →