Anagen

pathway activity — cross-omics
GO:0042640Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Anagen pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVPL, FERMT1, and CYP1B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCEVPL →+0.647+0.173<.001<.00136
GBMFERMT1 →+0.694+0.158<.001<.00135
LUADCYP1B1 →-0.703-0.102<.001<.00135
LSCCEVPL_S2025 →+0.769+0.123<.001<.00135
LSCCDLG5 →+0.256+0.120<.001<.00135
CCRCCDES_S432 →-1.896-0.137<.001.00534
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration