Anagen

pathway activity — cross-omics
GO:0042640Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Anagen pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PERP, TMEM117, and PLCL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCPERP →+0.886+0.224<.001.00434
LSCCTMEM117 →+0.617+0.208<.001<.00134
LSCCPLCL2 →-0.322-0.152.003.00534
LSCCPGAP4 →+0.897+0.222<.001<.00134
LSCCCLEC4D →-0.579-0.212<.001.00334
LSCCNMRAL2P →+2.374+0.217<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration