Anagen

pathway activity — cross-omics
GO:0042640Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Anagen pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JUP, GPX2, and CTNNB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCJUP →+0.750+0.227<.001<.00135
LSCCGPX2 →+1.212+0.239<.001<.00134
BRCACTNNB1 →+0.352+0.151<.001<.00134
PDACCTNNB1_S191 →+1.167+0.297<.001<.00134
PDACCTNNB1_S675 →+1.406+0.375<.001<.00134
PDACDSP_S2551 →+1.977+0.287<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration