Regulation of hair cycle

Across TCGA patient cohorts, RNA activity of the Regulation of hair cycle pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FSTL1, TGFB2, and MMP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hair cycle activity versus FSTL1 in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FSTL1 →	+0.477	+0.047	<.001	<.001	3	6
BRCA	TGFB2 →	+0.565	+0.055	<.001	<.001	3	6
BRCA	MMP1 →	+0.963	+0.048	<.001	<.001	3	6
BRCA	FBLIM1 →	+0.527	+0.066	<.001	<.001	3	6
BRCA	PLAU →	+0.498	+0.051	<.001	<.001	3	6
BRCA	CALU →	+0.415	+0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042634 vs FSTL1 — BRCA

Explore this scatter interactively →