Regulation of hair cycle

Across TCGA cell cohorts, RNA activity of the Regulation of hair cycle pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FXYD3, NFIC, and NECTIN4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hair cycle activity versus FXYD3 in OESOPHAGUS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FXYD3 →	+3.831	+0.539	.001	<.001	3	6
PANCREAS	NFIC →	-1.018	-0.370	.008	.001	3	6
STOMACH	NECTIN4 →	+2.760	+0.375	.002	.003	3	6
LUNG_SCLC	TMC4 →	+2.575	+0.281	<.001	.007	3	6
LUNG_NSCLC_LUAD	OVOL1 →	+1.671	+0.576	<.001	<.001	3	6
LUNG_SCLC	PKP3 →	+3.333	+0.332	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042634 vs FXYD3 — OESOPHAGUS

Explore this scatter interactively →