Fear response

Across TCGA patient cohorts, RNA activity of the Fear response pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATXN2, REM2_S68, and ANKIB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fear response activity versus ATXN2 in BRCA (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATXN2 →	+0.174	+0.025	.008	.007	3	5
GBM	REM2_S68 →	+0.887	+0.070	<.001	<.001	3	4
GBM	ANKIB1 →	+0.213	+0.053	.001	<.001	3	4
BRCA	RBMS1 →	-0.570	-0.031	<.001	<.001	3	4
COAD	DPP4 →	+0.566	+0.019	.001	.001	3	4
UCEC	GRHPR_S36 →	+0.221	+0.040	.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042596 vs ATXN2 — BRCA

Explore this scatter interactively →