Fear response

Across TCGA pan-cancer cohorts, RNA activity of the Fear response pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as UCEC and BRCA, show the opposite pattern, with lower activity in tumor tissue.

LIHC, THCA, and UCEC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LIHC	Male	III,IV	+0.045	<.001	8	view →
THCA	All	All	+0.025	<.001	8	view →
UCEC	All	II,III,IV	−0.042	.002	6	view →
BRCA	Female	II,III,IV	−0.024	<.001	6	view →
COAD	All	All	−0.019	<.001	6	view →
CHOL	All	All	+0.056	<.001	3	view →
BLCA	All	IV	−0.048	.016	3	view →
PRAD	All	All	+0.031	<.001	2	view →
READ	All	All	−0.032	.023	1	view →
HNSC	Male	III,IV	−0.024	.028	1	view →
LUAD	Male	III,IV	−0.021	.021	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0042596–LIHC

Open the LIHC breakdown →