Fear response

Across TCGA patient cohorts, RNA activity of the Fear response pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK2, WDHD1, and DEPDC1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fear response activity versus NEK2 in BRCA (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NEK2 →	-0.800	-0.333	.001	.002	3	4
LSCC	WDHD1 →	-0.474	-0.175	<.001	.005	3	4
LSCC	DEPDC1B →	-0.729	-0.271	<.001	<.001	3	4
LSCC	CDKN3 →	-0.503	-0.201	.001	.001	3	4
OV	RAD51AP1 →	-0.970	-0.319	<.001	.001	3	4
OV	TMPO →	-0.627	-0.240	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042596 vs NEK2 — BRCA

Explore this scatter interactively →