Fear response

Across TCGA cell cohorts, RNA activity of the Fear response pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DBT, PIK3C2B, and ITPKC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DBT grouped by Fear response-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DBT →	+0.516	+1.573	.001	<.001	3	4
URINARY_TRACT	PIK3C2B →	+2.335	+1.871	.009	<.001	3	4
URINARY_TRACT	ITPKC →	+2.170	+1.995	.001	<.001	3	4
OESOPHAGUS	DTX4 →	+2.302	+1.474	<.001	<.001	3	4
OESOPHAGUS	MPZL2 →	+1.259	+1.211	.007	.003	3	4
KIDNEY	SLC35E3 →	+0.788	+1.121	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DBT by Fear response activity — LIVER

Explore this box plot interactively →