Antigen processing and presentation of exogenous peptide antigen via MHC class I

Across TCGA cell cohorts, RNA activity of the Antigen processing and presentation of exogenous peptide antigen via MHC class I pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDF9, NDUFA4L2, and GGA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GDF9 grouped by Antigen processing and presentation of exogenous peptide antigen via MHC class I-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GDF9 →	+0.548	+1.276	.006	<.001	3	4
BLOOD_Leukemia	NDUFA4L2 →	-1.221	-1.345	.006	.002	3	4
CNS	GGA2 →	+0.787	+0.982	.008	.005	3	4
STOMACH	FBXL4 →	+0.651	+0.900	.002	.005	3	4
BONE	RENBP →	+2.444	+1.418	.006	.007	3	4
BONE	KCNQ4 →	+1.837	+1.682	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GDF9 by Antigen processing and presentation of exogenous peptide antigen via MHC class I activity — LUNG_SCLC

Explore this box plot interactively →