Antigen processing and presentation of exogenous peptide antigen via MHC class I

Across TCGA pan-cancer cohorts, RNA activity of the Antigen processing and presentation of exogenous peptide antigen via MHC class I pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as HNSC and COAD, show the opposite pattern, with lower activity in tumor tissue.

KIRC, HNSC, and COAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.051	<.001	11	view →
HNSC	Male	IV	−0.074	<.001	8	view →
COAD	Female	All	−0.043	<.001	8	view →
LUSC	Female	All	−0.094	<.001	7	view →
UCEC	All	All	−0.053	<.001	6	view →
LUAD	All	II,III,IV	−0.050	.001	6	view →
BRCA	All	All	−0.025	<.001	6	view →
LIHC	Female	All	+0.042	<.001	4	view →
CHOL	All	All	+0.083	<.001	3	view →
KICH	All	All	−0.035	.013	2	view →
ESCA	Female	All	−0.073	.034	1	view →
BLCA	Male	IV	−0.052	.031	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0042590–KIRC

Open the KIRC breakdown →