Retinal metabolic process

Across TCGA patient cohorts, RNA activity of the Retinal metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C3, ATRX, and BOD1L1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinal metabolic process activity versus AKR1C3 in UCEC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKR1C3 →	+1.242	+0.077	<.001	<.001	3	8
COAD	ATRX →	-0.297	-0.041	<.001	<.001	3	6
HNSC	BOD1L1 →	-0.194	-0.069	<.001	<.001	3	6
HNSC	CEP170 →	-0.253	-0.095	<.001	<.001	3	6
UCEC	DHRS3 →	+0.573	+0.047	<.001	<.001	3	6
UCEC	ARHGEF37 →	+0.587	+0.063	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042574 vs AKR1C3 — UCEC

Explore this scatter interactively →