Retinal metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Retinal metabolic process pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 18 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Retinal metabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and ACC, show the opposite pattern, with higher activity associated with better survival.

SCLC, KIRP, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.204	0.600	<.001	62	view →
KIRP	DFS	Quartile	III,IV	0.784	0.292	.002	44	view →
ACC	DFS	Tertile	All	0.730	0.291	<.001	32	view →
READ	DFS	Quartile	III,IV	0.563	1.000	.004	27	view →
ESCA	DFS	Median	III,IV	0.551	0.310	.008	24	view →
MESO	DFS	Tertile	All	0.469	0.295	.016	22	view →
THYM	OS	Median	II,III,IV	0.669	1.000	.005	18	view →
PAAD	OS	Median	All	0.238	0.465	.003	16	view →
COAD	DFS	Tertile	IV	0.759	0.354	.028	13	view →
STAD	OS	Quartile	IV	0.197	0.572	.016	9	view →
SKCM	DFS	Quartile	II,III,IV	0.139	0.338	.005	8	view →
LUAD	DFS	Median	All	0.617	0.698	.023	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0042574–SCLC (DFS)

Open the SCLC breakdown →