Retinal metabolic process

Across TCGA patient cohorts, RNA activity of the Retinal metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RDH10, PLAC9, and AOC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinal metabolic process activity versus RDH10 in LUAD (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RDH10 →	+0.868	+0.131	<.001	<.001	3	6
OV	PLAC9 →	+0.954	+0.191	.001	.001	3	6
OV	AOC3 →	+1.366	+0.192	<.001	.002	3	6
GBM	CYP1B1 →	+1.402	+0.190	<.001	<.001	3	5
GBM	FAM20A →	+0.728	+0.173	<.001	<.001	3	5
LSCC	ZBTB16 →	+1.183	+0.188	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042574 vs RDH10 — LUAD

Explore this scatter interactively →