Retinal metabolic process

Across TCGA cell cohorts, RNA activity of the Retinal metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCO1, ABCA4, and HHLA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCO1 grouped by Retinal metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BCO1 →	-0.389	-1.200	<.001	<.001	3	7
PANCREAS	ABCA4 →	-0.233	-1.101	.007	.003	2	8
LUNG_NSCLC_LUAD	HHLA2 →	-0.186	-0.949	.001	.002	3	6
KIDNEY	BCO2 →	-0.388	-1.280	.002	.002	2	6
CNS	LIPI →	-0.223	-1.342	.006	<.001	3	4
CNS	CELA2B →	-0.280	-0.906	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCO1 by Retinal metabolic process activity — CNS

Explore this box plot interactively →