Pteridine-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Pteridine-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN10, RALGAPA1, and TSPAN33, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pteridine-containing compound metabolic process activity versus CAPN10 in PANCREAS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CAPN10 →	+0.636	+0.280	.005	.005	3	6
PANCREAS	RALGAPA1 →	+0.745	+0.309	.006	.003	3	6
LIVER	TSPAN33 →	+3.152	+0.407	<.001	.001	3	5
LARGE_INTESTINE	MNX1 →	+1.198	+0.234	<.001	<.001	3	5
BREAST	DDHD1 →	+0.929	+0.273	<.001	.001	3	5
BLOOD_Leukemia	ADCK2 →	+1.046	+0.185	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042558 vs CAPN10 — PANCREAS

Explore this scatter interactively →