Negative regulation of tyrosine phosphorylation of STAT protein

Across TCGA patient cohorts, RNA activity of the Negative regulation of tyrosine phosphorylation of STAT protein pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1S, ITIH2, and F13A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of tyrosine phosphorylation of STAT protein activity versus C1S in BRCA (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C1S →	+0.534	+0.042	<.001	<.001	3	7
PDAC	ITIH2 →	+0.548	+0.053	<.001	<.001	3	7
GBM	F13A1 →	+0.930	+0.102	<.001	<.001	3	7
GBM	SERPINA4 →	+0.485	+0.059	<.001	<.001	3	6
UCEC	SYNPO →	+0.552	+0.092	<.001	<.001	3	6
GBM	TLN1 →	+0.352	+0.088	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042532 vs C1S — BRCA

Explore this scatter interactively →