Positive regulation of odontogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of odontogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB44, NACA2, and PUM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB44 grouped by Positive regulation of odontogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZBTB44 →	-0.536	-0.741	.007	<.001	3	5
LUNG_SCLC	NACA2 →	-0.319	-1.780	.004	<.001	3	4
SOFT_TISSUE	PUM1 →	-0.562	-1.142	.003	.001	3	3
SOFT_TISSUE	PLXNB1 →	-1.693	-1.546	.002	<.001	3	3
BLOOD_Myeloma	LTB4R →	+0.948	+1.012	.003	.009	3	3
BREAST	MSANTD2 →	-0.528	-0.697	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB44 by Positive regulation of odontogenesis activity — BREAST

Explore this box plot interactively →