Outer ear morphogenesis

Across TCGA patient cohorts, RNA activity of the Outer ear morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOK3_S364, RARA, and SAMHD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outer ear morphogenesis activity versus DOK3_S364 in CCRCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DOK3_S364 →	-0.727	-0.070	<.001	.001	2	6
CCRCC	RARA →	+0.439	+0.059	.002	.001	3	5
CCRCC	SAMHD1 →	-0.395	-0.094	<.001	<.001	3	5
LSCC	SEPTIN1_S315 →	-0.589	-0.048	.002	.001	3	5
LSCC	WDFY4 →	-0.307	-0.053	<.001	<.001	3	5
CCRCC	LPXN →	-0.587	-0.099	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042473 vs DOK3_S364 — CCRCC

Explore this scatter interactively →