Inner ear morphogenesis

Across TCGA patient cohorts, RNA activity of the Inner ear morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOK2, UTRN, and PRKCD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner ear morphogenesis activity versus DOK2 in CCRCC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DOK2 →	-0.290	-0.029	<.001	<.001	3	6
UCEC	UTRN →	+0.326	+0.067	.001	<.001	3	6
HNSC	PRKCD →	-0.232	-0.042	.002	<.001	3	6
CCRCC	TNFAIP8 →	-0.320	-0.034	.001	<.001	3	5
UCEC	CORO1A →	-0.508	-0.056	.002	.004	3	5
UCEC	DOCK10 →	-0.389	-0.064	.009	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042472 vs DOK2 — CCRCC

Explore this scatter interactively →