Inner ear morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Inner ear morphogenesis pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 104 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Inner ear morphogenesis pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and GBM, show the opposite pattern, with higher activity associated with better survival.

UVM, KIRC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.761	0.372	<.001	88	view →
KIRC	DFS	Median	All	0.825	0.895	.002	81	view →
MESO	OS	Quartile	All	0.362	0.707	<.001	63	view →
LAML	DFS	Tertile	All	0.284	0.500	.012	30	view →
SARC	DFS	Tertile	All	0.360	0.664	<.001	29	view →
GBM	DFS	Quartile	All	0.419	0.204	.001	25	view →
KIRP	DFS	Median	III,IV	0.760	0.145	.013	24	view →
COAD	OS	Quartile	All	0.936	0.782	.005	22	view →
HNSC	DFS	Median	IV	0.409	0.218	.001	21	view →
UCEC	DFS	Median	IV	0.863	0.519	.002	18	view →
LUSC	DFS	Median	All	0.720	0.605	.002	18	view →
READ	DFS	Tertile	IV	0.253	0.860	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0042472–UVM (OS)

Open the UVM breakdown →