Inner ear morphogenesis

Across TCGA patient cohorts, RNA activity of the Inner ear morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB1, SCIMP, and EOMES, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner ear morphogenesis activity versus LILRB1 in COAD (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LILRB1 →	-0.737	-0.579	<.001	.008	3	5
COAD	SCIMP →	-0.513	-0.809	.001	<.001	3	5
COAD	EOMES →	-0.622	-0.597	<.001	.009	3	5
COAD	TRIP13 →	-0.465	-0.466	.001	.009	3	5
UCEC	ANKRD36BP2 →	-0.766	-0.204	.001	<.001	3	5
COAD	CD40 →	-0.744	-0.665	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042472 vs LILRB1 — COAD

Explore this scatter interactively →