Inner ear morphogenesis

Across TCGA cell cohorts, RNA activity of the Inner ear morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRHL1, FUT9, and SLC48A1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRHL1 grouped by Inner ear morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GRHL1 →	+1.171	+1.724	<.001	<.001	3	3
BLOOD_Myeloma	FUT9 →	+1.014	+1.508	.009	<.001	3	3
BLOOD_Myeloma	SLC48A1 →	-0.787	-1.525	<.001	<.001	3	3
CNS	ZSCAN5A →	-0.632	-0.945	<.001	<.001	3	3
CNS	SCG2 →	+2.800	+0.941	<.001	<.001	3	3
CNS	H3C1 →	-0.294	-0.731	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRHL1 by Inner ear morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →