Inner ear morphogenesis

Across TCGA cell cohorts, RNA activity of the Inner ear morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS7, CREM, and TMEM150A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner ear morphogenesis activity versus ADAMTS7 in LIVER (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ADAMTS7 →	-1.382	-0.059	.001	.001	3	8
OESOPHAGUS	CREM →	-1.058	-0.079	.009	<.001	2	8
BLOOD_Lymphoma	TMEM150A →	-0.992	-0.039	<.001	<.001	3	7
BREAST	SLC22A17 →	-1.268	-0.036	.002	.004	3	7
LIVER	ITGAX →	-1.533	-0.063	.004	.001	3	7
CNS	PRRT3 →	-0.835	-0.034	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042472 vs ADAMTS7 — LIVER

Explore this scatter interactively →