Inner ear morphogenesis

Across TCGA cell cohorts, RNA activity of the Inner ear morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHROOM1, CTTNBP2NL, and SAMD9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner ear morphogenesis activity versus SHROOM1 in BLOOD_Lymphoma (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SHROOM1 →	-1.100	-0.292	.006	.006	3	5
BLOOD_Lymphoma	CTTNBP2NL →	-1.206	-0.485	<.001	<.001	3	4
BLOOD_Lymphoma	SAMD9 →	-2.003	-0.439	<.001	.001	3	4
LUNG_NSCLC_LUAD	RAB11FIP1 →	+1.355	+0.341	.002	.007	3	4
LUNG_NSCLC_LUSC	CFAP45 →	-0.694	-0.216	.005	.009	3	4
STOMACH	PIAS3 →	-1.588	-0.330	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042472 vs SHROOM1 — BLOOD_Lymphoma

Explore this scatter interactively →