Purine nucleoside biosynthetic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADA, MTAP, and THEMIS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside biosynthetic process activity versus ADA in PDAC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ADA →	+0.495	+0.049	.001	<.001	3	7
HNSC	MTAP →	+0.642	+0.081	<.001	<.001	3	6
GBM	THEMIS2 →	+0.344	+0.053	<.001	<.001	3	6
GBM	ELMO1 →	+0.427	+0.054	<.001	<.001	3	6
OV	NRBF2 →	+0.486	+0.047	<.001	<.001	3	5
GBM	ARHGAP4 →	+0.357	+0.051	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042451 vs ADA — PDAC

Explore this scatter interactively →