Purine nucleoside biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Purine nucleoside biosynthetic process pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Purine nucleoside biosynthetic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and SKCM, show the opposite pattern, with higher activity associated with better survival.

UVM, LUAD, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.318	0.599	<.001	104	view →
LUAD	OS	Median	All	0.242	0.423	<.001	89	view →
STAD	OS	Tertile	All	0.307	0.566	.001	63	view →
LIHC	OS	Tertile	All	0.361	0.590	.001	53	view →
UCS	DFS	Tertile	II,III,IV	0.567	0.148	.020	42	view →
SCLC	DFS	Median	III,IV	0.304	0.620	.011	34	view →
KIRP	DFS	Median	All	0.862	0.959	.001	31	view →
ACC	DFS	Median	II,III,IV	0.374	0.667	.002	24	view →
UCEC	DFS	Quartile	All	0.609	0.757	.002	20	view →
PAAD	DFS	Median	All	0.196	0.373	.003	20	view →
SKCM	DFS	Quartile	All	0.253	0.146	.010	17	view →
KIRC	DFS	Median	III,IV	0.388	0.534	.039	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0042451–UVM (DFS)

Open the UVM breakdown →