Purine nucleoside biosynthetic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCR5, ZC3H12D, and ARHGAP25, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside biosynthetic process activity versus CCR5 in PDAC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CCR5 →	+0.470	+0.111	.008	.003	3	8
UCEC	ZC3H12D →	+0.689	+0.150	<.001	.002	3	7
UCEC	ARHGAP25 →	+0.732	+0.151	<.001	.003	3	7
COAD	LILRB4 →	+0.722	+0.136	<.001	.001	3	7
BRCA	FAM78A →	+0.574	+0.123	<.001	.005	3	6
OV	P2RY8 →	+0.711	+0.169	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042451 vs CCR5 — PDAC

Explore this scatter interactively →