Purine nucleoside biosynthetic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HPRT1, SRSF9, and CENPM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside biosynthetic process activity versus HPRT1 in LIVER (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HPRT1 →	+1.098	+1.734	.002	.001	3	6
PANCREAS	SRSF9 →	+0.825	+1.352	.001	<.001	3	5
URINARY_TRACT	CENPM →	+1.280	+1.459	<.001	<.001	3	5
URINARY_TRACT	RRM2 →	+1.185	+1.459	<.001	<.001	3	5
PANCREAS	POLR1B →	+0.781	+1.195	<.001	<.001	3	5
KIDNEY	JPT1 →	+1.272	+1.427	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042451 vs HPRT1 — LIVER

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