Hormone metabolic process

Across TCGA patient cohorts, RNA activity of the Hormone metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HCFC1, NASP, and LMNB1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hormone metabolic process activity versus HCFC1 in GBM (Pearson r = -0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HCFC1 →	-0.231	-0.022	<.001	<.001	3	9
GBM	NASP →	-0.464	-0.021	<.001	<.001	3	9
GBM	LMNB1 →	-0.337	-0.028	<.001	<.001	3	9
BRCA	SMCHD1 →	-0.299	-0.016	<.001	<.001	3	8
GBM	SF3A1 →	-0.239	-0.026	<.001	<.001	3	8
BRCA	TRIM33_S862 →	-0.620	-0.016	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042445 vs HCFC1 — GBM

Explore this scatter interactively →