Ethanolamine-containing compound metabolic process

pathway activity — cross-omics
GO:0042439Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Ethanolamine-containing compound metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GDPD3, PLS1, and HNMT, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVGDPD3 →+1.254+0.059<.001<.00137
OVPLS1 →+0.546+0.041.002.00735
LUADHNMT →+0.368+0.055.001.00235
LUADHOPX →+0.453+0.057.001.00135
LUADMAPK3 →+0.302+0.084<.001<.00135
BRCASYNPO2_S363 →+1.030+0.034.001.00635
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration