Ethanolamine-containing compound metabolic process

pathway activity — cross-omics
GO:0042439Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Ethanolamine-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM38A, USP1, and HSPB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCTMEM38A →+0.486+0.279.005.00233
GBMUSP1 →-0.300-0.117.007<.00133
UCECHSPB1 →+0.990+0.176.008.00733
UCECPLEKHG6 →+0.641+0.231<.001<.00133
COADRPS3AP13 →+0.197+0.161.002.00324
LUADGDPD3 →+0.817+0.196<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration