Indole-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Indole-containing compound metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMB10, WAS, and HCLS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Indole-containing compound metabolic process activity versus PSMB10 in OV (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PSMB10 →	+0.403	+0.042	<.001	.001	3	9
GBM	WAS →	+0.603	+0.064	<.001	<.001	3	8
GBM	HCLS1 →	+0.716	+0.057	<.001	<.001	3	8
GBM	LCP1 →	+0.879	+0.066	<.001	<.001	3	8
GBM	LCP2 →	+0.509	+0.060	<.001	<.001	3	8
GBM	LPXN →	+0.534	+0.043	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042430 vs PSMB10 — OV

Explore this scatter interactively →