Indole-containing compound metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Indole-containing compound metabolic process pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 24 member genes.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher Indole-containing compound metabolic process pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and KIRP, show the opposite pattern, with higher activity associated with better survival.

READ, STAD, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	III,IV	0.884	0.615	<.001	69	view →
STAD	DFS	Quartile	All	0.235	0.613	<.001	63	view →
KIRP	OS	Tertile	II,III,IV	1.000	0.290	.006	61	view →
KIRC	DFS	Tertile	All	0.899	0.725	.004	52	view →
ESCA	DFS	Median	All	0.436	0.631	.003	46	view →
OV	OS	Median	III,IV	0.867	0.803	.007	38	view →
LIHC	DFS	Tertile	All	0.477	0.340	.001	37	view →
UVM	DFS	Tertile	All	1.000	0.291	.005	21	view →
CHOL	DFS	Quartile	All	0.819	0.120	.001	20	view →
SKCM	OS	Quartile	All	0.419	0.270	.008	14	view →
GBM	DFS	Median	All	0.204	0.389	.013	12	view →
COAD	DFS	Tertile	II,III,IV	0.813	0.698	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0042430–READ (DFS)

Open the READ breakdown →