Indole-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Indole-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPA1, TUBB, and TARBP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Indole-containing compound metabolic process activity versus RPA1 in LUAD (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPA1 →	-0.325	-0.245	<.001	<.001	3	4
LUAD	TUBB →	-0.413	-0.206	.001	.006	3	4
CCRCC	TARBP2 →	-0.394	-0.210	<.001	<.001	3	4
CCRCC	ZFP69B →	-0.306	-0.183	.008	.005	3	4
UCEC	PIK3CG →	+0.503	+0.168	.001	.004	3	3
UCEC	PLA2G2D →	+1.334	+0.290	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042430 vs RPA1 — LUAD

Explore this scatter interactively →