Indole-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Indole-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOM1L1, SH3BGRL2, and HLA-F, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TOM1L1 grouped by Indole-containing compound metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TOM1L1 →	+0.896	+1.419	.002	.003	3	3
OESOPHAGUS	SH3BGRL2 →	+1.586	+1.353	.002	<.001	3	3
OESOPHAGUS	HLA-F →	+2.058	+1.113	.006	.007	3	3
OESOPHAGUS	RPL31 →	+0.816	+1.069	.007	.006	3	3
BREAST	PKD2 →	+1.117	+0.767	.006	.007	3	3
BREAST	RGL1 →	+1.136	+0.883	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TOM1L1 by Indole-containing compound metabolic process activity — OESOPHAGUS

Explore this box plot interactively →