Indole-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Indole-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFV1, RNF43, and LIN52, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Indole-containing compound metabolic process activity versus NDUFV1 in SKIN (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NDUFV1 →	+0.525	+0.590	.006	.009	3	4
BLOOD_Lymphoma	RNF43 →	+1.592	+0.782	.006	.006	3	4
BLOOD_Leukemia	LIN52 →	+0.407	+0.719	.004	.003	3	3
PANCREAS	TPST2 →	-1.341	-1.348	.004	.002	3	3
PANCREAS	TMEM243 →	-0.723	-0.925	.003	.001	3	3
PANCREAS	CD82 →	-2.599	-1.377	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042430 vs NDUFV1 — SKIN

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