Dopamine metabolic process

Across TCGA patient cohorts, RNA activity of the Dopamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPG, LMNB1, and CDC20, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopamine metabolic process activity versus NCAPG in UCEC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPG →	-0.981	-0.133	<.001	<.001	3	6
UCEC	LMNB1 →	-0.985	-0.139	<.001	<.001	3	6
UCEC	CDC20 →	-1.653	-0.134	<.001	<.001	3	6
BRCA	CENPF →	-0.861	-0.136	.001	.001	3	6
UCEC	KIF14 →	-0.729	-0.105	<.001	<.001	3	6
BRCA	KIF18A →	-0.657	-0.163	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042417 vs NCAPG — UCEC

Explore this scatter interactively →