Dopamine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Dopamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC5A1, POLA1, and KCND1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopamine biosynthetic process activity versus SLC5A1 in LUNG_SCLC (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC5A1 →	+1.296	+1.874	.004	<.001	3	1
LUNG_SCLC	POLA1 →	+0.677	+2.044	.002	<.001	3	1
LUNG_SCLC	KCND1 →	-0.726	-1.874	<.001	<.001	3	1
LUNG_SCLC	RASA4 →	-1.025	-1.955	.006	<.001	3	1
LUNG_SCLC	PSMD3 →	-1.086	-1.874	.002	<.001	3	1
LUNG_SCLC	WNT3 →	-2.916	-2.277	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042416 vs SLC5A1 — LUNG_SCLC

Explore this scatter interactively →