Vitamin D biosynthetic process

Across TCGA patient cohorts, RNA activity of the Vitamin D biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNAI1, CYP27B1, and ITGA5, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin D biosynthetic process activity versus SNAI1 in KICH (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	SNAI1 →	+1.168	+0.050	.001	<.001	1	26
GBM	CYP27B1 →	+1.728	+0.058	<.001	<.001	3	22
DLBC	ITGA5 →	+1.267	+0.058	<.001	<.001	3	22
LAML	TNFRSF4 →	+1.530	+0.066	.001	.005	1	24
MESO	ADAMTS4 →	+1.437	+0.037	.001	.004	2	23
BLCA	PRKAR1B-AS1 →	+0.955	+0.049	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042368 vs SNAI1 — KICH

Explore this scatter interactively →