Vitamin D biosynthetic process

Across TCGA patient cohorts, RNA activity of the Vitamin D biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK10, WAS, and THEMIS2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin D biosynthetic process activity versus STK10 in GBM (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STK10 →	+0.442	+0.101	<.001	<.001	3	10
GBM	WAS →	+0.617	+0.090	<.001	<.001	3	10
LSCC	THEMIS2 →	+0.492	+0.092	<.001	<.001	3	9
HNSC	WDFY4 →	+0.470	+0.114	<.001	<.001	3	9
GBM	WIPF1 →	+0.415	+0.107	<.001	<.001	3	9
COAD	CCDC88B →	+0.748	+0.043	.002	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042368 vs STK10 — GBM

Explore this scatter interactively →