Vitamin D metabolic process

Across TCGA patient cohorts, RNA activity of the Vitamin D metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP27A1, MS4A4A, and ITM2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin D metabolic process activity versus CYP27A1 in LUAD (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CYP27A1 →	+0.915	+0.164	<.001	<.001	3	5
LSCC	MS4A4A →	+0.620	+0.918	.004	<.001	3	5
CCRCC	ITM2B →	+0.389	+0.198	.001	.003	3	4
OV	ALOX5 →	+1.016	+0.194	.003	.001	3	4
LUAD	FTL →	+0.362	+0.248	.006	.002	3	4
CCRCC	LRP2 →	+1.750	+0.286	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042359 vs CYP27A1 — LUAD

Explore this scatter interactively →