Vasodilation

Across TCGA patient cohorts, RNA activity of the Vasodilation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAVIN1_S118, CD34, and NID2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vasodilation activity versus CAVIN1_S118 in BRCA (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAVIN1_S118 →	+1.251	+0.044	<.001	<.001	3	9
CCRCC	CD34 →	+0.872	+0.067	<.001	<.001	3	9
COAD	NID2 →	+0.483	+0.045	<.001	<.001	3	9
GBM	SYNC →	+0.573	+0.062	<.001	<.001	3	9
UCEC	RSU1 →	+0.445	+0.051	<.001	<.001	3	8
BRCA	SERPINF1 →	+0.792	+0.030	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042311 vs CAVIN1_S118 — BRCA

Explore this scatter interactively →