Vasodilation

Across TCGA patient cohorts, RNA activity of the Vasodilation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNE4, CNRIP1, and MMP19, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vasodilation activity versus KCNE4 in OV (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KCNE4 →	+1.124	+0.125	.004	.002	3	6
OV	CNRIP1 →	+0.926	+0.127	<.001	<.001	3	6
BRCA	MMP19 →	+0.770	+0.254	.002	<.001	3	6
OV	ADGRL4 →	+0.887	+0.150	<.001	<.001	3	6
GBM	S1PR1 →	+0.948	+0.544	<.001	<.001	3	6
GBM	MYLK →	+0.751	+0.430	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042311 vs KCNE4 — OV

Explore this scatter interactively →