Vasodilation

Across TCGA cell cohorts, RNA activity of the Vasodilation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD3, ZNF816, and PRDX3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHD3 grouped by Vasodilation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CHD3 →	+1.134	+0.257	.006	.001	3	4
OESOPHAGUS	ZNF816 →	+1.835	+0.301	.002	.006	3	3
LIVER	PRDX3 →	+0.446	+0.327	.004	.001	3	3
CNS	TMC6 →	-1.676	-0.268	.002	<.001	2	4
SOFT_TISSUE	N4BP2L1 →	+0.960	+0.392	.004	<.001	3	3
URINARY_TRACT	KRT36 →	-0.105	-0.270	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHD3 by Vasodilation activity — URINARY_TRACT

Explore this box plot interactively →