Vasoconstriction

Across TCGA patient cohorts, RNA activity of the Vasoconstriction pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR36, COIL_T303, and NOL6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vasoconstriction activity versus WDR36 in OV (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WDR36 →	-0.342	-0.033	.001	<.001	3	8
BRCA	COIL_T303 →	-1.059	-0.035	<.001	<.001	3	8
LSCC	NOL6 →	-0.268	-0.045	<.001	<.001	3	8
GBM	SF3A2 →	-0.309	-0.054	<.001	<.001	3	8
GBM	TCERG1 →	-0.269	-0.049	<.001	<.001	3	8
BRCA	UTP18 →	-0.307	-0.026	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042310 vs WDR36 — OV

Explore this scatter interactively →