Vasoconstriction

Across TCGA cell cohorts, RNA activity of the Vasoconstriction pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT27, POLA1, and DSE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFT27 grouped by Vasoconstriction-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IFT27 →	+1.273	+0.938	.004	.006	3	4
BLOOD_Leukemia	POLA1 →	+0.759	+0.734	.001	.001	3	4
BLOOD_Leukemia	DSE →	+0.943	+0.664	<.001	.004	3	4
KIDNEY	IFI27L1 →	+0.909	+0.861	.001	<.001	3	4
LUNG_NSCLC_LUAD	TRERF1 →	+1.025	+0.226	<.001	<.001	3	4
LARGE_INTESTINE	HAUS8 →	+0.627	+0.941	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFT27 by Vasoconstriction activity — LARGE_INTESTINE

Explore this box plot interactively →