Vasoconstriction

Across TCGA cell cohorts, RNA activity of the Vasoconstriction pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAPLN, SLC22A15, and SLC12A8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vasoconstriction activity versus PAPLN in OVARY (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PAPLN →	-1.404	-0.187	<.001	.007	3	6
BLOOD_Leukemia	SLC22A15 →	-1.032	-0.091	.002	.002	3	6
SOFT_TISSUE	SLC12A8 →	-1.578	-0.245	<.001	<.001	3	6
BLOOD_Lymphoma	GPR68 →	-1.737	-0.168	.002	.001	3	6
SOFT_TISSUE	MT2A →	-2.744	-0.190	<.001	<.001	3	6
SOFT_TISSUE	RAC2 →	-2.632	-0.253	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042310 vs PAPLN — OVARY

Explore this scatter interactively →