Vasoconstriction

Across TCGA cell cohorts, RNA activity of the Vasoconstriction pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF13, TRAPPC2B, and E2F2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vasoconstriction activity versus TAF13 in OESOPHAGUS (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TAF13 →	+1.061	+1.075	.001	.002	3	5
LUNG_NSCLC_LUAD	TRAPPC2B →	+1.190	+1.268	.002	<.001	3	4
BLOOD_Leukemia	E2F2 →	+2.205	+1.083	<.001	<.001	3	4
SOFT_TISSUE	NOCT →	+1.038	+1.745	.004	<.001	3	4
BLOOD_Lymphoma	PSRC1 →	+1.561	+1.525	.003	<.001	3	4
BLOOD_Leukemia	MED9 →	+0.776	+0.912	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042310 vs TAF13 — OESOPHAGUS

Explore this scatter interactively →